Motif ID: HOX{A4,D4}.p2

Z-value: 1.052


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA4chr7_-_27136876-0.351.9e-01Click!
HOXD4chr2_+_1767243580.029.4e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_205161821 1.283 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr11_-_16380967 1.056 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr11_+_5329313 0.778 NM_001004750
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr6_+_50894397 0.763 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr5_-_168204430 0.753


chr2_+_182558795 0.696 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_+_53177789 0.671 NCKAP1L
NCK-associated protein 1-like
chr12_+_53177806 0.659 NCKAP1L
NCK-associated protein 1-like
chr3_-_57209319 0.658 NM_003865
HESX1
HESX homeobox 1
chr12_+_53177758 0.657 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr17_-_36181927 0.629 NM_181539
KRT26
keratin 26
chr3_+_182900081 0.624 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr9_+_263025 0.624 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr6_-_32892705 0.622 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_+_58369392 0.620 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr13_-_19703371 0.601 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr11_-_5178505 0.598 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr1_-_114215768 0.596 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr7_+_143423073 0.592 NM_001004135
OR2A12
olfactory receptor, family 2, subfamily A, member 12
chr11_+_71605466 0.574 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr5_+_149131695 0.566 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_-_108032645 0.557 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_-_115380539 0.548 NM_000796
NM_033663
DRD3

dopamine receptor D3

chrX_+_79562601 0.527 NM_152630
FAM46D
family with sequence similarity 46, member D
chrX_+_134482212 0.526 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chrX_-_19598912 0.523 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr12_+_53178834 0.518 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr17_-_36165050 0.512 NM_181534
KRT25
keratin 25
chrX_+_37524250 0.507 CYBB
cytochrome b-245, beta polypeptide
chrX_-_123925343 0.502 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr12_-_10464308 0.491 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr6_-_27988152 0.489 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr7_+_1239078 0.483 NM_001080461
UNCX
UNC homeobox
chr7_+_143683365 0.468 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr10_+_68355797 0.467 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr1_-_205272619 0.455 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr13_+_77007809 0.452 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr22_+_21065134 0.448 LOC100290481
immunoglobulin lambda light chain-like
chrX_-_84521398 0.446 NM_024921
POF1B
premature ovarian failure, 1B
chrX_+_144710557 0.439 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr17_-_36779399 0.436 NM_002279
KRT33B
keratin 33B
chrX_+_37524190 0.434 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr6_+_132915522 0.434 NM_053278
TAAR8
trace amine associated receptor 8
chr7_-_143523582 0.432 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chrX_-_84521320 0.422 POF1B
premature ovarian failure, 1B
chr7_-_143622188 0.421 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr17_-_36276987 0.421 NM_000223
KRT12
keratin 12
chr5_+_140481763 0.419 NM_018938
PCDHB4
protocadherin beta 4
chr4_-_47678187 0.419 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr6_-_116973465 0.415 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr6_+_50789215 0.414 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr11_-_119514058 0.414 NM_012101
TRIM29
tripartite motif containing 29
chr6_+_32713160 0.413 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_+_1109619 0.409 NM_014461
CNTN6
contactin 6
chrX_+_109548940 0.402 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr10_+_118177371 0.393 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr5_-_56814310 0.388 NM_001017992
ACTBL2
actin, beta-like 2
chr20_-_30703219 0.376 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr1_+_159943385 0.376 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr10_+_91051685 0.374 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chrX_+_65152004 0.366


chr12_-_51086330 0.361 NM_033033
KRT82
keratin 82
chr15_-_19007127 0.360 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr1_+_158426908 0.355 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr17_-_8711701 0.354 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr12_+_111713931 0.352 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr3_+_2528272 0.352 CNTN4
contactin 4
chr1_+_65503011 0.350 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr13_+_42034871 0.349 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chrX_-_15312390 0.344 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr1_-_158883666 0.339 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr8_-_87824996 0.336 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr18_-_68683913 0.336 NM_138999
NM_153181
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chr8_+_11388918 0.335 NM_001715
BLK
B lymphoid tyrosine kinase
chr3_+_160269836 0.335 IQCJ
IQ motif containing J
chr19_+_54128750 0.335 NM_014475
DHDH
dihydrodiol dehydrogenase (dimeric)
chr11_-_13474101 0.334 NM_000315
PTH
parathyroid hormone
chr7_+_106897737 0.331 NM_005295
GPR22
G protein-coupled receptor 22
chr12_-_92001543 0.327 RPL41P5
ribosomal protein L41 pseudogene 5
chr2_+_113542017 0.326 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr6_+_105511615 0.321 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr2_-_113526910 0.317 NM_014438
NM_173178
IL1F8

interleukin 1 family, member 8 (eta)

chrX_-_131401319 0.316 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr4_-_151990061 0.315 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr2_-_215605054 0.312 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr2_-_70634129 0.310 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr11_-_5110383 0.310 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr4_+_119174947 0.307 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr2_+_172530120 0.306 HAT1
histone acetyltransferase 1
chr18_+_27210737 0.305 NM_001134453
NM_177986
DSG4

desmoglein 4

chr4_-_123761615 0.304 NM_021803
IL21
interleukin 21
chr19_+_14554895 0.302 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr15_+_88545510 0.302 NM_198925
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr12_+_47205681 0.301 NM_001005203
OR8S1
olfactory receptor, family 8, subfamily S, member 1
chr11_-_117589283 0.301 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr9_+_126460511 0.298


chr12_-_7793335 0.297 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr4_-_38710376 0.295 NM_024943
TMEM156
transmembrane protein 156
chrX_+_134482387 0.295 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr12_-_101398429 0.294 IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_+_5466490 0.294 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr10_-_69095362 0.291 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chrX_-_11194015 0.290 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr13_-_83354474 0.289 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr1_+_207668787 0.288 NM_001104548
LOC642587
NPC-A-5
chr19_-_7672978 0.287 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr5_-_95044415 0.286 NM_031952
SPATA9
spermatogenesis associated 9
chrX_+_12795111 0.284 NM_016562
TLR7
toll-like receptor 7
chr11_+_5925152 0.284 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr16_-_56562512 0.282 NM_001135639
NM_001297
CNGB1

cyclic nucleotide gated channel beta 1

chr6_+_154449334 0.279 NM_001145287
OPRM1
opioid receptor, mu 1
chr15_+_38319326 0.279 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_4466684 0.278 NM_001005171
OR52K1
olfactory receptor, family 52, subfamily K, member 1
chr2_+_79593679 0.277 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr5_-_147142444 0.277 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr3_+_99288706 0.277 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chrX_+_99726445 0.276 NM_022144
TNMD
tenomodulin
chr11_+_59979857 0.275 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr19_+_55965532 0.274 NM_001506
GPR32
G protein-coupled receptor 32
chr5_+_176494690 0.271 NSD1
nuclear receptor binding SET domain protein 1
chr6_+_28032997 0.271 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr4_+_71298187 0.269 NM_021225
PROL1
proline rich, lacrimal 1
chr2_+_17861266 0.265 NM_001105569
MSGN1
mesogenin 1
chr1_+_559618 0.263


chr4_+_71235259 0.262 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr2_+_225973845 0.262 NM_020864
KIAA1486
KIAA1486
chr7_+_128293699 0.261 NM_001195150
LOC100130705
hypothetical protein LOC100130705
chr1_+_556968 0.260


chrX_+_92815667 0.260 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr18_+_59295123 0.259 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr5_-_14706486 0.258


chr12_-_7547552 0.258 NM_004244
NM_203416
CD163

CD163 molecule

chr1_+_159959072 0.257 NM_001002901
FCRLB
Fc receptor-like B
chr1_-_203579932 0.257 KLHDC8A
kelch domain containing 8A
chr1_+_559129 0.256


chr1_+_198263352 0.255 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr3_-_74652952 0.255 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr10_-_105835609 0.254 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr4_+_70928718 0.253 NM_000200
HTN3
histatin 3
chrX_-_137649180 0.253 NM_033642
FGF13
fibroblast growth factor 13
chr17_-_3408038 0.253 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr1_-_42738535 0.251 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr5_-_147142457 0.251 JAKMIP2
janus kinase and microtubule interacting protein 2
chr3_-_191322919 0.251 NM_001134418
LEPREL1
leprecan-like 1
chr1_-_150029529 0.248 NM_001083963
NM_001083964
NM_001083965
NM_006862
TDRKH



tudor and KH domain containing



chr12_-_54150188 0.247 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr9_+_74326536 0.247 NM_138691
TMC1
transmembrane channel-like 1
chr4_-_64957595 0.246 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr4_-_40212670 0.246 NM_019027
RBM47
RNA binding motif protein 47
chr18_+_59705918 0.244 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr7_+_116447499 0.244 ST7
suppression of tumorigenicity 7
chr1_-_158815850 0.244 CD84
CD84 molecule
chr21_-_30460841 0.244 NM_012131
CLDN17
claudin 17
chr14_-_104602784 0.243 NM_013345
GPR132
G protein-coupled receptor 132
chr1_-_158759606 0.243 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr7_+_141457977 0.241 LOC93432
maltase-glucoamylase-like pseudogene
chr5_-_147142249 0.241 JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_+_938709 0.241 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr9_+_92629525 0.240 NM_001174167
SYK
spleen tyrosine kinase
chr9_+_86474445 0.240 NM_001007097
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr11_-_119514011 0.239 TRIM29
tripartite motif containing 29
chr13_-_83354425 0.238 SLITRK1
SLIT and NTRK-like family, member 1
chr17_+_51585834 0.235 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr10_+_129237602 0.235 NM_001030013
NPS
neuropeptide S
chr11_-_5037432 0.231 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr14_-_104602809 0.231 GPR132
G protein-coupled receptor 132
chr19_-_47623340 0.231 NM_005357
LIPE
lipase, hormone-sensitive
chr1_-_156923111 0.229 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_+_142590633 0.228 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr7_-_138014329 0.228 NM_001139456
SVOPL
SVOP-like
chr8_+_19840861 0.228 NM_000237
LPL
lipoprotein lipase
chr7_-_143622233 0.225 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr10_-_123343320 0.225 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr4_+_71492581 0.223 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr1_-_167947301 0.223 NM_000655
SELL
selectin L
chr1_+_40631603 0.221 NM_001198979
SMAP2
small ArfGAP2
chr12_-_101398470 0.221 IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_+_69356827 0.220 NM_001178087
NM_022978
NM_021967
NM_022968
SERF1B

SERF1A

small EDRK-rich factor 1B (centromeric)

small EDRK-rich factor 1A (telomeric)

chr19_-_20399601 0.220 ZNF826P
zinc finger protein 826, pseudogene
chr1_-_34404029 0.219 NM_052896
CSMD2
CUB and Sushi multiple domains 2
chr19_-_55560686 0.218 NM_004851
NAPSA
napsin A aspartic peptidase
chr12_-_11030777 0.218 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr14_+_19458580 0.218 NM_001005483
OR4K5
olfactory receptor, family 4, subfamily K, member 5
chr16_+_56286212 0.218 NM_032269
CCDC135
coiled-coil domain containing 135
chr17_-_36209672 0.217 NM_181535
KRT28
keratin 28
chr4_-_72868598 0.216 NM_000583
GC
group-specific component (vitamin D binding protein)
chr15_-_70838703 0.216


chr12_-_52016270 0.216 NM_001173467
SP7
Sp7 transcription factor
chr11_-_102250876 0.216 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr4_-_74704964 0.215 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr3_-_18455207 0.215 NM_001131010
SATB1
SATB homeobox 1
chr7_+_128802719 0.215 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr1_-_149004852 0.214 CTSS
cathepsin S
chr2_-_158008763 0.214 NM_004288
CYTIP
cytohesin 1 interacting protein
chr11_+_125163215 0.214 NM_001129883
PATE3
prostate and testis expressed 3
chr2_+_113591940 0.213 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr14_-_56342097 0.212 NM_172337
OTX2
orthodenticle homeobox 2
chr13_-_46368968 0.212 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr19_+_17723285 0.212 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chrX_-_114158388 0.211 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.98 2.77e-07 GO:0007606 sensory perception of chemical stimulus
1.68 1.57e-06 GO:0007600 sensory perception
1.92 1.87e-05 GO:0007608 sensory perception of smell
1.17 4.52e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 7.93e-04 GO:0005886 plasma membrane
1.19 8.71e-04 GO:0071944 cell periphery
1.27 6.33e-03 GO:0005576 extracellular region
1.14 1.94e-02 GO:0031224 intrinsic to membrane
1.13 3.87e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.51 1.66e-09 GO:0004872 receptor activity
1.69 9.43e-08 GO:0004930 G-protein coupled receptor activity
1.41 1.22e-07 GO:0004871 signal transducer activity
1.41 1.22e-07 GO:0060089 molecular transducer activity
1.52 6.37e-07 GO:0004888 transmembrane receptor activity
1.94 5.84e-06 GO:0004984 olfactory receptor activity